@article {807,
	title = {Clinical applications of biomarkers in pediatric traumatic brain injury.},
	journal = {Childs Nerv Syst},
	volume = {26},
	year = {2010},
	month = {2010 Feb},
	pages = {205-13},
	abstract = {INTRODUCTION: The diagnosis, treatment, and prediction of outcome in pediatric traumatic brain injury (TBI) present significant challenges to the treating clinician. Clinical and radiological tools for assessing injury severity and predicting outcome, in particular, lack sensitivity and specificity. In patients with mild TBI, often there is uncertainty about which patients should undergo radiological imaging and who is at risk for long term neurological sequelae. In severe TBI, often there is uncertainty about which patients will experience secondary insults and what the outcome for individual patients will be. In several other clinical specialties, biomarkers are used to diagnose disease, direct treatment, and prognosticate. However, an ideal biomarker for brain injury has not been found.

METHODS: In this review, we examine the various factors that must be taken into account in the search for a reliable biomarker in brain injury. We review the important studies that have investigated common biomarkers of structural brain injury, in particular S100B, neuron-specific enolase, myelin basic protein, and glial fibrillary acid protein.

DISCUSSION: The potential uses and limitations of these biomarkers in the context of TBI are discussed.},
	keywords = {Animals, Biological Markers, Brain Injuries, Child, Humans},
	issn = {1433-0350},
	doi = {10.1007/s00381-009-1009-1},
	author = {Sandler, Simon J I and Figaji, Anthony A and Adelson, P David}
}
@article {815,
	title = {Intracranial pressure and cerebral oxygenation changes after decompressive craniectomy in a child with traumatic brain swelling.},
	journal = {Childs Nerv Syst},
	volume = {23},
	year = {2007},
	month = {2007 Nov},
	pages = {1331-5},
	abstract = {CASE REPORT: The authors present the case of a 5-year-old child with severe traumatic brain injury in whom decompressive hemicraniectomy was performed for progressive increased intracranial pressure (ICP) unresponsive to medical treatment. Data from ICP and cerebral tissue oxygenation monitoring in the contralateral hemisphere were recorded, which demonstrated the immediate and delayed mechanical and physiological changes occurring after bony and dural decompression. DISCUSSION: The role of the procedure and that of the monitoring approach are discussed.},
	keywords = {Brain Edema, Brain Injuries, Cerebrum, Child, Preschool, Craniotomy, Decompression, Surgical, Functional Laterality, Humans, Hypoxia, Brain, Intracranial Hypertension, Male, Oxygen, Treatment Outcome},
	issn = {0256-7040},
	doi = {10.1007/s00381-007-0388-4},
	author = {Figaji, A A and Fieggen, A G and Sandler, S J I and Argent, A C and Le Roux, P D and Peter, J C}
}
