@article {707,
	title = {Extracellular simian virus 40 induces an ERK/MAP kinase-independent signalling pathway that activates primary response genes and promotes virus entry.},
	journal = {J Gen Virol},
	volume = {77 ( Pt 9)},
	year = {1996},
	month = {1996 Sep},
	pages = {2173-82},
	abstract = {Simian virus 40 (SV40) binding to growth-arrested cells activated an intracellular signalling pathway that induced the up-regulation of the primary response genes c-myc, c-jun and c-sis within 30 min and of JE within 90 min. The up-regulation of the primary response genes occurred in the presence of cycloheximide and when UV-inactivated SV40 was adsorbed to cells. SV40 binding did not activate Raf or mitogen-activated protein kinase (MAP/ERK1), or mobilize intracellular Ca2+. The SV40-induced up-regulation of c-myc and c-jun was blocked by the tyrosine kinase inhibitor, genistein, and by the protein kinase C (PKC) inhibitor, calphostin C, but not by expression of the MAP kinase-specific phosphatase, MKP-1. These results suggest that the SV40-induced signalling pathway includes the activities of a tyrosine kinase and a Ca(2+)-independent isoform of PKC, but not of Raf or MAP kinase. Finally, SV40 infectious entry into cells was specifically and reversibly blocked by genistein.},
	keywords = {Animals, Calcium, Calcium-Calmodulin-Dependent Protein Kinases, Cell Cycle Proteins, Cell Line, Cercopithecus aethiops, Dual Specificity Phosphatase 1, Enzyme Inhibitors, Gene Expression Regulation, Viral, Genistein, Humans, Immediate-Early Proteins, Isoflavones, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinases, Naphthalenes, Phosphoprotein Phosphatases, Platelet-Derived Growth Factor, Protein Kinase C, Protein Phosphatase 1, Protein Tyrosine Phosphatases, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-jun, Proto-Oncogene Proteins c-myc, Proto-Oncogene Proteins c-raf, Proto-Oncogene Proteins c-sis, Signal Transduction, Simian virus 40, Up-Regulation},
	issn = {0022-1317},
	author = {Dangoria, N S and Breau, W C and Anderson, H A and Cishek, D M and Norkin, L C}
}
@article {705,
	title = {Relationship between expression of epidermal growth factor and simian virus 40 T antigen in a line of transgenic mice.},
	journal = {Transgenic Res},
	volume = {4},
	year = {1995},
	month = {1995 Sep},
	pages = {306-14},
	abstract = {The pattern of expression of the simian virus 40 (SV40) T antigen gene and resultant dysplasia were re-examined in a line of transgenic mice in which the T antigen gene was under the control of the SV40 early promoter. We found that T antigen expression in the kidney, and resulting dysplastic lesions, occurred exclusively in the distal convoluted tubules and the ascending limbs of Henle. Epidermal growth factor (EGF) expression in the kidney of normal mice was similarly immunolocalized. The correlation between high EGF immunoreactivity in normal mouse tissues and T antigen expression in the transgenic counterpart was also seen in the choroid plexus epithelium and in the submandibular glands of male mice. T antigen was not found in the submandibular gland of transgenic females. Similarly, EGF was only rarely detected in the normal female submandibular gland. In contrast to the correlation between T antigen expression in the transgenic mice and EGF expression in the corresponding tissues of the normal mice, within the dysplastic lesions of the transgenic mice EGF expression was severely diminished. Adenocarcinomas of the male submandibular gland from another line of transgenic mice that expresses the Int-1 transgene, showed similarly reduced levels of immunostaining for EGF. Thus, reduced expression of EGF might be a general feature of dysplasia and tumorigenesis in those tissues that normally express EGF.},
	keywords = {Adenocarcinoma, Animals, Antigens, Viral, Tumor, Cattle, Choroid Plexus, Cricetinae, Epidermal Growth Factor, Female, Gene Expression Regulation, Neoplastic, Kidney, Kidney Tubules, Distal, Male, Mice, Mice, Transgenic, Proto-Oncogene Proteins, Simian virus 40, Submandibular Gland, Submandibular Gland Neoplasms, Wnt Proteins, Wnt1 Protein, Zebrafish Proteins},
	issn = {0962-8819},
	author = {Lafond, R E and Giammalvo, J T and Norkin, L C}
}
